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Synthesis of (+)-Bullatacin via the Highly Diastereoselective [3+2] Annulation Reaction of a Racemic Aldehyde and a Non-Racemic Allylsilane

A total synthesis of (+)-bullatacin has been accomplished via a diastereoselective [3+2] annulation reaction of the highly enantiomerically enriched allylsilane 3 and racemic aldehyde 4, which provides the key bis-tetrahydrofuran fragment 15 with ≥ 20 : 1 ds.

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Detalhes bibliográficos
Main Authors: Tinsley, Jennifer M., Mertz, Eric, Chong, Pek Y., Rarig, Robert-André F., Roush, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2507730/
https://ncbi.nlm.nih.gov/pubmed/16146398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol051719k
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