Conformational change in the floor of the human rhinovirus canyon blocks adsorption to HeLa cell receptors.

A series of eight antiviral compounds complexed with human rhinovirus 14 (HRV-14) were previously shown to displace segments of polypeptide chains in the floor of the "canyon" by as much as 0.45 nm in C-alpha positions from the native conformation (J. Badger, I. Minor, M. J. Kremer, M. A....

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Autors principals: Pevear, D C, Fancher, M J, Felock, P J, Rossmann, M G, Miller, M S, Diana, G, Treasurywala, A M, McKinlay, M A, Dutko, F J
Format: Artigo
Idioma:Inglês
Publicat: 1989
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC250615/
https://ncbi.nlm.nih.gov/pubmed/2539499
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