Mapping of attenuating sequences of an avirulent poliovirus type 2 strain.
A mouse model for poliomyelitis was used to identify genomic sequences that attenuate neurovirulence of poliovirus strain P2/P712. This type 2 strain is avirulent in primates and mice yet grows as well as virulent strains in cell culture. The approach used was to exchange portions of the genome of t...
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| Publicado no: | J Virol |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1989
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250599/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2539491/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.5.1884-1890.1989 |
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