Mapping of attenuating sequences of an avirulent poliovirus type 2 strain.

A mouse model for poliomyelitis was used to identify genomic sequences that attenuate neurovirulence of poliovirus strain P2/P712. This type 2 strain is avirulent in primates and mice yet grows as well as virulent strains in cell culture. The approach used was to exchange portions of the genome of t...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Moss, E G, O'Neill, R E, Racaniello, V R
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1989
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC250599/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2539491/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.5.1884-1890.1989
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