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Structural changes of membrane-anchored native PrP(C)

Misfolding and subsequent aggregation of endogeneous proteins constitute essential steps in many human disorders, including Alzheimer and prion diseases. In most prion protein-folding studies, the posttranslational modifications, the lipid anchor in particular, were lacking. Here, we studied a fully...

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Hlavní autoři: Elfrink, Kerstin, Ollesch, Julian, Stöhr, Jan, Willbold, Dieter, Riesner, Detlev, Gerwert, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504809/
https://ncbi.nlm.nih.gov/pubmed/18669653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804721105
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