Translesion Synthesis past Equine Estrogen-derived 2′-Deoxyadenosine DNA adducts by Human DNA polymerases η and κ

Hormone replacement therapy (HRT) increases the risk of developing breast, ovarian and endometrial cancers. Equilin and equilenin are the major components of the widely prescribed drug used for HRT. 4-hydroxyequilenin (4-OHEN), a major metabolite of equilin and equilenin, promotes 4-OHEN-modified dC...

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Main Authors: Yasui, Manabu, Santosh Laxmi, Y. R., Ananthoju, Sreenivasa R., Suzuki, Naomi, Kim, Sung Yeon, Shibutani, Shinya
Format: Artigo
Jezik:Inglês
Izdano: 2006
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504361/
https://ncbi.nlm.nih.gov/pubmed/16681391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0525324
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