Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells

Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix (ECM) and basement membrane. Expression of the heparanase gene is associated with the invasion and metastatic potential of a variety of tumor-derived cell types. However, t...

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Bibliographic Details
Main Authors: Hong, Xin, Jiang, Feng, Kalkanis, Steven N, Zhang, Zheng Gang, Zhang, Xuepeng, Zheng, Xuguang, Jiang, Hao, Mikkelsen, Tom, Chopp, Michael
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2499998/
https://ncbi.nlm.nih.gov/pubmed/18647407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-27-23
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