Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells

Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix (ECM) and basement membrane. Expression of the heparanase gene is associated with the invasion and metastatic potential of a variety of tumor-derived cell types. However, t...

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Bibliographische Detailangaben
Hauptverfasser: Hong, Xin, Jiang, Feng, Kalkanis, Steven N, Zhang, Zheng Gang, Zhang, Xuepeng, Zheng, Xuguang, Jiang, Hao, Mikkelsen, Tom, Chopp, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2499998/
https://ncbi.nlm.nih.gov/pubmed/18647407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-27-23
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