Thermodynamic stability of wild-type and mutant p53 core domain

Some 50% of human cancers are associated with mutations in the core domain of the tumor suppressor p53. Many mutations are thought just to destabilize the protein. To assess this and the possibility of rescue, we have set up a system to analyze the stability of the core domain and its mutants. The u...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Bullock, Alex N., Henckel, Julia, DeDecker, Brian S., Johnson, Christopher M., Nikolova, Penka V., Proctor, Mark R., Lane, David P., Fersht, Alan R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences of the USA 1997
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC24967/
https://ncbi.nlm.nih.gov/pubmed/9405613
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk