Thermodynamic stability of wild-type and mutant p53 core domain
Some 50% of human cancers are associated with mutations in the core domain of the tumor suppressor p53. Many mutations are thought just to destabilize the protein. To assess this and the possibility of rescue, we have set up a system to analyze the stability of the core domain and its mutants. The u...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24967/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14338 |
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