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Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for TDBzl-etomidate, a Photoreactive Positive Allosteric Effector

Etomidate, one of the most potent general anesthetics used clinically, acts at micromolar concentrations as an anesthetic and positive allosteric modulator of γ-aminobutyric acid responses, whereas it inhibits muscle-type nicotinic acetylcholine receptors (nAChRs) at concentrations above 10 μm. We r...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nirthanan, Selvanayagam, Garcia, Galo, Chiara, David C., Husain, S. Shaukat, Cohen, Jonathan B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494931/
https://ncbi.nlm.nih.gov/pubmed/18524766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801332200
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