The Preference of Tryptophan for Membrane Interfaces: INSIGHTS FROM N-METHYLATION OF TRYPTOPHANS IN GRAMICIDIN CHANNELS

To better understand the structural and functional roles of tryptophan at the membrane/water interface in membrane proteins, we examined the structural and functional consequences of Trp → 1-methyl-tryptophan substitutions in membrane-spanning gramicidin A channels. Gramicidin A channels are minipro...

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Autores principales: Sun, Haiyan, Greathouse, Denise V., Andersen, Olaf S., Koeppe, Roger E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Membrane Transport, Structure, Function, and Biogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494914/
https://ncbi.nlm.nih.gov/pubmed/18550546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802074200
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