Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone

RhoA/Rho kinase (ROCK) signaling plays a key role in the pathogenesis of experimental pulmonary hypertension (PH). Dehydroepiandrosterone (DHEA), a naturally occurring steroid hormone, effectively inhibits chronic hypoxic PH, but the responsible mechanisms are unclear. This study tested whether DHEA...

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Autors principals: Homma, Noriyuki, Nagaoka, Tetsutaro, Karoor, Vijaya, Imamura, Masatoshi, Taraseviciene-Stewart, Laimute, Walker, Lori A., Fagan, Karen A., McMurtry, Ivan F., Oka, Masahiko
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494797/
https://ncbi.nlm.nih.gov/pubmed/18469113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90251.2008
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