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Low Dose Monocrotaline Causes a Selective Pulmonary Vascular Lesion in Male and Female Pneumonectomized Rats
PURPOSE/AIM: Low doses (30–80 mg/kg) of monocrotaline are commonly used to create experimental models of pulmonary hypertension in rats. At these doses, monocrotaline causes pulmonary endothelial apoptosis and acute lung injury which ultimately resolves into pulmonary vascular disease. Higher doses...
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| Publicado no: | Exp Lung Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6240164/ https://ncbi.nlm.nih.gov/pubmed/29381088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/01902148.2017.1422157 |
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