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Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress

In sickle cell disease, nitric oxide (NO) depletion by cell-free plasma hemoglobin and/or oxygen radicals is associated with arginine deficiency, impaired NO bioavailability, and chronic oxidative stress. In transgenic-knockout sickle (BERK) mice that express exclusively human α- and β(S)-globins, r...

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Bibliographische Detailangaben
Hauptverfasser: Kaul, Dhananjay K., Zhang, Xiaoqin, Dasgupta, Trisha, Fabry, Mary E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494769/
https://ncbi.nlm.nih.gov/pubmed/18456737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00162.2008
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