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Mice overexpressing latent TGF-β1 are protected against renal fibrosis in obstructive kidney disease
Transforming growth factor (TGF)-β1, once activated, binds to its receptors and mediates renal fibrosis via the downstream Smad signaling pathway. We reported here that mice overexpressing latent TGF-β1 in keratinocytes were protected against renal fibrosis in a model of obstructive kidney disease....
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2494503/ https://ncbi.nlm.nih.gov/pubmed/18448597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00021.2008 |
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