α(4)β(1)-Integrin regulates directionally persistent cell migration in response to shear flow stimulation

α(4)β(1)-Integrin plays a pivotal role in cell migration in vivo. This integrin has been shown to regulate the front-back polarity of migrating cells via localized inhibition of α(4)-integrin/paxillin binding by phosphorylation at the α(4)-integrin cytoplasmic tail. Here, we demonstrate that α(4)β(1...

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Bibliographic Details
Main Authors: Dikeman, Dustin A., Rivera Rosado, Leslie A., Horn, Troy A., Alves, Christina S., Konstantopoulos, Konstantinos, Yang, Joy T.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2008
Subjects:
Extracellular Matrix, Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493558/
https://ncbi.nlm.nih.gov/pubmed/18495811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00169.2008
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