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Carcinoembryonic Antigen and CD44 Variant Isoforms Cooperate to Mediate Colon Carcinoma Cell Adhesion to E- and L-selectin in Shear Flow

Selectin-mediated adhesion of tumor cells to platelets, leukocytes, and endothelial cells may regulate their hematogenous dissemination in the microvasculature. We recently identified CD44 variant isoforms (CD44v) as functional P-, but not E- or L-, selectin ligands on colon carcinoma cells. Moreove...

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Autores principales: Thomas, Susan N., Zhu, Fei, Schnaar, Ronald L., Alves, Christina S., Konstantopoulos, Konstantinos
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2414264/
https://ncbi.nlm.nih.gov/pubmed/18375392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800543200
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