Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite

Cultured vascular endothelial cell (EC) exposure to steady laminar shear stress results in peroxynitrite (ONOO(−)) formation intramitochondrially and inactivation of the electron transport chain. We examined whether the “hyperoxic state” of 21% O(2), compared with more physiological O(2) tensions (P...

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Detalhes bibliográficos
Main Authors: Jones, Charles I., Han, Zhaosheng, Presley, Tennille, Varadharaj, Saradhadevi, Zweier, Jay L., Ilangovan, Govindasamy, Alevriadou, B. Rita
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2008
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493556/
https://ncbi.nlm.nih.gov/pubmed/18480296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00549.2007
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