Pathogenic Autoantibodies in Systemic Lupus Erythematosus Are Derived from Both Self-Reactive and Non-Self–Reactive B Cells

Previous studies have shown that both murine and human anti-double-stranded DNA (anti-dsDNA) antibodies can develop from non-DNA–reactive B cells and suggest a crucial role for somatic mutation in dsDNA binding. However, since only a limited number of human anti-dsDNA antibodies have been analyzed p...

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Bibliografiske detaljer
Main Authors: Zhang, Jie, Jacobi, Annett M, Wang, Tao, Diamond, Betty
Format: Artigo
Sprog:Inglês
Udgivet: ScholarOne 2008
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493535/
https://ncbi.nlm.nih.gov/pubmed/18677426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/2008-00066.Zhang
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