A systematic analysis of intronic sequences downstream of 5′ splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation

To identify human intronic sequences associated with 5′ splice site recognition, we performed a systematic search for motifs enriched in introns downstream of both constitutive and alternative cassette exons. Significant enrichment was observed for U-rich motifs within 100 nucleotides downstream of...

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Bibliografiske detaljer
Main Authors: Aznarez, Isabel, Barash, Yoseph, Shai, Ofer, He, David, Zielenski, Julian, Tsui, Lap-Chee, Parkinson, John, Frey, Brendan J., Rommens, Johanna M., Blencowe, Benjamin J.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2008
Fag:
Letter
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493427/
https://ncbi.nlm.nih.gov/pubmed/18456862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.073155.107
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