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Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding

Broad-spectrum matrix metalloproteinase (MMP) inhibitors (MMPI) were unsuccessful in cancer clinical trials, partly due to side effects resulting from limited knowledge of the full repertoire of MMP substrates, termed the substrate degradome, and hence the in vivo functions of MMPs. To gain further...

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Detalhes bibliográficos
Main Authors: Butler, Georgina S., Dean, Richard A., Tam, Eric M., Overall, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493375/
https://ncbi.nlm.nih.gov/pubmed/18505826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01775-07
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