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Towards third generation matrix metalloproteinase inhibitors for cancer therapy

The failure of matrix metalloproteinase (MMP) inhibitor drug clinical trials in cancer was partly due to the inadvertent inhibition of MMP antitargets that counterbalanced the benefits of MMP target inhibition. We explore how MMP inhibitor drugs might be developed to achieve potent selectivity for v...

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Detalhes bibliográficos
Main Authors: Overall, C M, Kleifeld, O
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361222/
https://ncbi.nlm.nih.gov/pubmed/16538215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603043
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