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Reactive-Site Cleavage Residues Confer Target Specificity to Baculovirus P49, a Dimeric Member of the P35 Family of Caspase Inhibitors

Baculovirus proteins P49 and P35 are potent suppressors of apoptosis in diverse organisms. Although related, P49 and P35 inhibit initiator and effector caspases, respectively, during infection of permissive insect cells. The molecular basis of this novel caspase specificity is unknown. To advance st...

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Main Authors: Guy, Michael P., Friesen, Paul D.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493353/
https://ncbi.nlm.nih.gov/pubmed/18508888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00231-08
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