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Crystal structure of baculovirus P35: role of a novel reactive site loop in apoptotic caspase inhibition.

The aspartate-specific caspases are critical protease effectors of programmed cell death and consequently represent important targets for apoptotic intervention. Baculovirus P35 is a potent substrate inhibitor of metazoan caspases, a property that accounts for its unique effectiveness in preventing...

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Main Authors: Fisher, A J, Cruz, W d, Zoog, S J, Schneider, C L, Friesen, P D
格式: Artigo
語言:Inglês
出版: 1999
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171287/
https://ncbi.nlm.nih.gov/pubmed/10205157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.8.2031
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