Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor.

Clonal deletion in the thymus by apoptosis is involved in purging the immune system of self-reactive T lymphocytes (negative selection). Cysteine proteases (caspases) belonging to the CPP32 family are activated during this process. We have produced transgenic mice expressing baculovirus p35, a broad...

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Bibliographic Details
Main Authors: Izquierdo, M, Grandien, A, Criado, L M, Robles, S, Leonardo, E, Albar, J P, de Buitrago, G G, Martínez-A, C
Format: Artigo
Language:Inglês
Published: 1999
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171111/
https://ncbi.nlm.nih.gov/pubmed/9878059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.1.156
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