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Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor.
Clonal deletion in the thymus by apoptosis is involved in purging the immune system of self-reactive T lymphocytes (negative selection). Cysteine proteases (caspases) belonging to the CPP32 family are activated during this process. We have produced transgenic mice expressing baculovirus p35, a broad...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171111/ https://ncbi.nlm.nih.gov/pubmed/9878059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.1.156 |
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