Role for Conserved Residues of Sindbis Virus Nonstructural Protein 2 Methyltransferase-Like Domain in Regulation of Minus-Strand Synthesis and Development of Cytopathic Infection

The plus-strand RNA genome of Sindbis virus (SINV) encodes four nonstructural proteins (nsP1 to nsP4) that are involved in the replication of the viral RNA. The ∼800-amino-acid nsP2 consists of an N-terminal domain with nucleoside triphosphatase and helicase activities and a C-terminal protease doma...

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Bibliographic Details
Main Authors: Mayuri, Geders, Todd W., Smith, Janet L., Kuhn, Richard J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493352/
https://ncbi.nlm.nih.gov/pubmed/18495773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00224-08
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