Limited Maintenance of Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8 T-Cell Receptor Clonotypes after Virus Challenge

T-cell receptors (TCRs) govern the specificity, efficacy, and cross-reactivity of CD8 T cells. Here, we studied CD8 T-cell clonotypes from Mane-A*10(+) pigtail macaques responding to the simian immunodeficiency virus (SIV) Gag KP9 epitope in a setting of vaccination and subsequent viral challenge. W...

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Autors principals: Smith, Miranda Z., Asher, Tedi E., Venturi, Vanessa, Davenport, Miles P., Douek, Daniel C., Price, David A., Kent, Stephen J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493343/
https://ncbi.nlm.nih.gov/pubmed/18508897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00607-08
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