Shiga Toxin 2 Causes Apoptosis in Human Brain Microvascular Endothelial Cells via C/EBP Homologous Protein

Shiga toxin 1 (Stx1) and Stx2 produced by Escherichia coli O157 are known to be cytotoxic to Vero and HeLa cells by inhibiting protein synthesis and by inducing apoptosis. In the present study, we have demonstrated that 10 ng/ml Stx2 induced DNA fragmentation in human brain microvascular endothelial...

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Bibliografische gegevens
Hoofdauteurs: Fujii, Jun, Wood, Katie, Matsuda, Fumiko, Carneiro-Filho, Benedito A., Schlegel, Keilo H., Yutsudo, Takashi, Binnington-Boyd, Beth, Lingwood, Clifford A., Obata, Fumiko, Kim, Kwang S., Yoshida, Shin-ichi, Obrig, Tom
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2008
Onderwerpen:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493216/
https://ncbi.nlm.nih.gov/pubmed/18541659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01581-07
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