Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells

This study aimed to identify signaling pathways that oppose connective tissue fibrosis in the aortic valve. Using valvular interstitial cells (VICs) isolated from porcine aortic valve leaflets, we show that basic fibroblast growth factor (FGF-2) effectively blocks transforming growth factor-β1 (TGF-...

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Bibliografiska uppgifter
Huvudupphovsmän: Cushing, Melinda C., Mariner, Peter D., Liao, Jo-Tsu, Sims, Evan A., Anseth, Kristi S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Federation of American Societies for Experimental Biology 2008
Ämnen:
Research Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493079/
https://ncbi.nlm.nih.gov/pubmed/18218921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-087627
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