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Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells
This study aimed to identify signaling pathways that oppose connective tissue fibrosis in the aortic valve. Using valvular interstitial cells (VICs) isolated from porcine aortic valve leaflets, we show that basic fibroblast growth factor (FGF-2) effectively blocks transforming growth factor-β1 (TGF-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Federation of American Societies for Experimental Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2493079/ https://ncbi.nlm.nih.gov/pubmed/18218921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-087627 |
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