Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells

We identified inhibitory peptide analogs (IPAs), capable of immunomodulating experimental autoimmune uveitis (EAU), induced in B10.RIII mice by immunization with the retinal antigen interphotoreceptor-binding protein in CFA. Alanine-substituted peptides of the major pathogenic epitope, residues 161–...

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Hlavní autoři: Cortes, Lizette M., Avichezer, Dody, Silver, Phyllis B., Luger, Dror, Mattapallil, Mary J., Chan, Chi-Chao, Caspi, Rachel R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Society for Leukocyte Biology 2008
Témata:
Translational and Clinical Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493072/
https://ncbi.nlm.nih.gov/pubmed/18495789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0308189
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