Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the genome-wi...

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Autors principals: Schumacher, Björn, van der Pluijm, Ingrid, Moorhouse, Michael J., Kosteas, Theodore, Robinson, Andria Rasile, Suh, Yousin, Breit, Timo M., van Steeg, Harry, Niedernhofer, Laura J., van IJcken, Wilfred, Bartke, Andrzej, Spindler, Stephen R., Hoeijmakers, Jan H. J., van der Horst, Gijsbertus T. J., Garinis, George A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493043/
https://ncbi.nlm.nih.gov/pubmed/18704162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000161
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