Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the genome-wi...

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Bibliografski detalji
Glavni autori: Schumacher, Björn, van der Pluijm, Ingrid, Moorhouse, Michael J., Kosteas, Theodore, Robinson, Andria Rasile, Suh, Yousin, Breit, Timo M., van Steeg, Harry, Niedernhofer, Laura J., van IJcken, Wilfred, Bartke, Andrzej, Spindler, Stephen R., Hoeijmakers, Jan H. J., van der Horst, Gijsbertus T. J., Garinis, George A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493043/
https://ncbi.nlm.nih.gov/pubmed/18704162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000161
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