PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element

The transcription factor PU.1 is an important regulator of hematopoiesis; precise expression levels are critical for normal hematopoietic development and suppression of leukemia. We show here that noncoding antisense RNAs are important modulators of proper dosages of PU.1. Antisense and sense RNAs a...

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Autors principals: Ebralidze, Alexander K., Guibal, Florence C., Steidl, Ulrich, Zhang, Pu, Lee, Sanghoon, Bartholdy, Boris, Jorda, Meritxell Alberich, Petkova, Victoria, Rosenbauer, Frank, Huang, Gang, Dayaram, Tajhal, Klupp, Johanna, O’Brien, Karen B., Will, Britta, Hoogenkamp, Maarten, Borden, Katherine L.B., Bonifer, Constanze, Tenen, Daniel G.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2008
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492744/
https://ncbi.nlm.nih.gov/pubmed/18676813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1654808
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