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The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock

A common feature of animal circadian clocks is the progressive phosphorylation of PERIOD (PER) proteins, which is highly dependent on casein kinase Iδ/ε (CKIδ/ε; termed DOUBLETIME [DBT] in Drosophila) and ultimately leads to the rapid degradation of hyperphosphorylated isoforms via a mechanism invol...

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Detaylı Bibliyografya
Asıl Yazarlar: Chiu, Joanna C., Vanselow, Jens T., Kramer, Achim, Edery, Isaac
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492663/
https://ncbi.nlm.nih.gov/pubmed/18593878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1682708
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