S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity

Glutamate/N-methyl-d-aspartate (NMDA) receptor-mediated neurotoxicity involves cyclooxygenase (COX)-2. We demonstrate that this neurotoxicity reflects activation of COX-2 by S-nitrosylation after selective binding of neuronal nitric oxide synthase (nNOS) to COX-2. nNOS, via its PDZ domain, binds COX...

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Detaylı Bibliyografya
Asıl Yazarlar: Tian, Jing, Kim, Sangwon F., Hester, Lynda, Snyder, Solomon H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492460/
https://ncbi.nlm.nih.gov/pubmed/18650379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804852105
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