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S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke

Overproduction of nitric oxide (NO) can cause neuronal damage, contributing to the pathogenesis of several neurodegenerative diseases and stroke (i.e., focal cerebral ischemia). NO can mediate neurotoxic effects at least in part via protein S-nitrosylation, a reaction that covalently attaches NO to...

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Detalhes bibliográficos
Main Authors: Shi, Zhong-Qing, Sunico, Carmen R., McKercher, Scott R., Cui, Jiankun, Feng, Gen-Sheng, Nakamura, Tomohiro, Lipton, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581884/
https://ncbi.nlm.nih.gov/pubmed/23382182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215501110
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