S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide

The activity of Cdk5 and its regulatory subunit p35 is thought to be important in both normal brain function and neurodegenerative disease pathogenesis. Increased Cdk5 activity, via proteolytic cleavage of p35 to a p25 fragment by the calcium-activated protease calpain or by phosphorylation at Cdk5(...

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Main Authors: Qu, Jing, Nakamura, Tomohiro, Cao, Gang, Holland, Emily A., McKercher, Scott R., Lipton, Stuart A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161554/
https://ncbi.nlm.nih.gov/pubmed/21844361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105172108
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