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ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo
The pathways that allow quiescent disseminated cancer cells to survive during prolonged dormancy periods are unknown. Here, we identify the transcription factor ATF6α as a pivotal survival factor for quiescent but not proliferative squamous carcinoma cells. ATF6α is essential for the adaptation of d...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2492459/ https://ncbi.nlm.nih.gov/pubmed/18650380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800939105 |
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