Загрузка...
Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes
While the QT/QTc interval is currently the best available clinical surrogate for the development of drug-induced torsades de pointes, it is overall an imperfect biomarker. In addition to low specificity for predicting arrhythmias, other issues relevant to using QT as a biomarker include (1) an appar...
Сохранить в:
| Главный автор: | |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2008
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2492101/ https://ncbi.nlm.nih.gov/pubmed/18536754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.222 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|