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Literature-based evaluation of four ‘hard endpoint' models for assessing drug-induced torsades de pointes liability
In safety pharmacology, a number of preclinical models for detecting drug-induced proarrhythmia liability have been recently introduced that utilize hard endpoints: early after depolarziations (EADs), torsades de pointes (TdP) or both as the principal biomarker. To explore the validity of four of th...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2492098/ https://ncbi.nlm.nih.gov/pubmed/18604235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.277 |
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