Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys

BACKGROUND AND PURPOSE: The non-selective β-adrenoceptor antagonist, D,L-sotalol (sotalol) is commonly employed as a positive control during preclinical cardiovascular safety pharmacology testing, mainly because of its ability to prolong QT interval duration. However, no information appears in the l...

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Detalhes bibliográficos
Main Authors: Lynch, J J, Wilson, A W, Hernandez, L E, Nelson, R A, Marsh, K C, Cox, B F, Mittelstadt, S W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492091/
https://ncbi.nlm.nih.gov/pubmed/18516073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.206
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