The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys

BACKGROUND AND PURPOSE: The effects of dofetilide were studied in monkeys and dogs. Pharmacokinetic data were generated together with the monitoring of cardiovascular changes in order to compare effects relative to human exposure. EXPERIMENTAL APPROACH: Beagle dogs and cynomolgus monkeys were teleme...

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Main Authors: Haushalter, T M, Friedrichs, G S, Reynolds, D L, Barecki-Roach, M, Pastino, G, Hayes, R, Bass, A S
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492096/
https://ncbi.nlm.nih.gov/pubmed/18604237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.275
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