DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

Sickle cell disease (SCD) is a debilitating monogenic blood disorder with a highly variable phenotype characterized by severe pain crises, acute clinical events, and early mortality. Interindividual variation in fetal hemoglobin (HbF) expression is a known and potentially heritable modifier of SCD s...

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Bibliografiset tiedot
Päätekijät: Lettre, Guillaume, Sankaran, Vijay G., Bezerra, Marcos André C., Araújo, Aderson S., Uda, Manuela, Sanna, Serena, Cao, Antonio, Schlessinger, David, Costa, Fernando F., Hirschhorn, Joel N., Orkin, Stuart H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2008
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2491485/
https://ncbi.nlm.nih.gov/pubmed/18667698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804799105
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