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Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

Cyclin D1 (CyD1) is a pivotal cell cycle-regulatory molecule and a well-studied therapeutic target for cancer. Although CyD1 is also strongly up-regulated at sites of inflammation, its exact roles in this context remain uncharacterized. To address this question, we developed a strategy for selective...

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Autori principali: Peer, Dan, Park, Eun Jeong, Morishita, Yoshiyuki, Carman, Christopher V., Shimaoka, Motomu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490797/
https://ncbi.nlm.nih.gov/pubmed/18239128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1149859
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