Site-specific Cleavage of G Protein-coupled Receptor-engaged β-Arrestin: INFLUENCE OF THE AT(1) RECEPTOR CONFORMATION ON SCISSILE SITE SELECTION

The discovery of β-arrestin-related ∼46-kDa polypeptide in transfected cells and mouse hearts led us to examine angiotensin II type 1 receptor (AT(1)R)-dependent proteolytic cleavage of β-arrestin(s). Receptor-ligand induced proteolysis of β-arrestin(s) is novel, especially in the endocrine system,...

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Bibliographische Detailangaben
Hauptverfasser: Lee, ChangWoo, Bhatt, Sumantha, Shukla, Anita, Desnoyer, Russell W., Yadav, Satya P., Kim, Mijin, Jang, Sei-Heon, Karnik, Sadashiva S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490789/
https://ncbi.nlm.nih.gov/pubmed/18505723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803062200
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