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Cooperative DNA Binding and Communication across the Dimer Interface in the TREX2 3′ → 5′-Exonuclease

The activity of human TREX2-catalyzed 3′ → 5′-deoxyribonuclease has been analyzed in steady-state and single turnover kinetic assays and in equilibrium DNA binding studies. These kinetic data provide evidence for cooperative DNA binding within TREX2 and for coordinated catalysis between the TREX2 ac...

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Bibliografische gegevens
Hoofdauteurs: Perrino, Fred W., de Silva, Udesh, Harvey, Scott, Pryor, Edward E., Cole, Daniel W., Hollis, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490786/
https://ncbi.nlm.nih.gov/pubmed/18534978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803629200
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