The Hereditary Hemochromatosis Protein, HFE, Inhibits Iron Uptake via Down-regulation of Zip14 in HepG2 Cells

Lack of functional hereditary hemochromatosis protein, HFE, causes iron overload predominantly in hepatocytes, the major site of HFE expression in the liver. In this study, we investigated the role of HFE in the regulation of both transferrin-bound iron (TBI) and non-transferrin-bound iron (NTBI) up...

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Hlavní autoři: Gao, Junwei, Zhao, Ningning, Knutson, Mitchell D., Enns, Caroline A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Molecular Basis of Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490774/
https://ncbi.nlm.nih.gov/pubmed/18524764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803150200
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